Recent Publications
Papinska JA, Durslewicz J, Bagavant H, Deshmukh US. Deleting mitochondrial superoxide dismutase 2 in salivary gland ductal epithelial cells recapitulates non-Sjogren’s sicca syndrome. Int J Mol Sci. 2024, 25(11), 5983; https://doi.org/10.3390/ijms25115983. https://www.mdpi.com/1422-0067/25/11/5983
Bagavant H, Durslewicz J, Pyclik M, Makuch M, Papinska JA, Deshmukh US. Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren’s-like disease in aging mice. Geroscience. 2024 Apr 24. doi: 10.1007/s11357-024-01159-3. Epub ahead of print. PMID: 38656650.
Huang KT, Wagner LE, Takano T, Lin XX, Bagavant H, Deshmukh U, Yule DI. Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren’s syndrome. bioRxiv [Preprint]. 2024 Mar 19:2024.03.19.585719. doi: 10.1101/2024.03.19.585719. PMID: 38562738; PMCID: PMC10983907.
Pyclik M, Durslewicz J, Papinska JA, Deshmukh US, Bagavant H. STING Agonist-Induced Skin Inflammation Is Exacerbated with Prior Systemic Innate Immune Activation. Int J Mol Sci. 2023 Feb 18;24(4):4128. doi: 10.3390/ijms24044128. PMID: 36835537; PMCID: PMC9960435.
Bagavant H, Araszkiewicz AM, Rasmussen A, Pezant N, Montgomery C, Scofield RH, Farris D, Lessard CJ, Deshmukh US. Anti-vimentin antibodies are associated with higher severity of Sjögren’s disease. Clin Immunol. 2023 Feb;247:109243. doi: 10.1016/j.clim.2023.109243. Epub 2023 Jan 24. PMID: 36702181; PMCID: PMC10037908.
Bagavant H, Trzeciak M, Biswas I, Papinska JA, Cizio K, Deshmukh US. Antibody deposition on vascular endothelial cells contributes to localized inflammation in salivary glands. J Oral Pathol Med. 2022 Aug;51(7):674-677. doi: 10.1111/jop.13330. Epub 2022 Jul 12. PMID: 35766433; PMCID: PMC9388553.
Bagavant H, Cizio K, Araszkiewicz AM, Papinska JA, Garman L, Li C, Pezant N, Drake WP, Montgomery CG, Deshmukh US. Systemic immune response to vimentin and granuloma formation in a model of pulmonary sarcoidosis. J Transl Autoimmun. 2022 Apr 5;5:100153. doi: 10.1016/j.jtauto.2022.100153. PMID: 35434591; PMCID: PMC9006845.
Bagavant H, Araszkiewicz AM, Ingram JK, Cizio K, Merrill JT, Arriens C, Guthridge JM, James JA, Deshmukh US. Immune Response to Enterococcus gallinarum in Lupus Patients Is Associated With a Subset of Lupus-Associated Autoantibodies. Front Immunol. 2021 May 28;12:635072. doi: 10.3389/fimmu.2021.635072. PMID: 34122404; PMCID: PMC8193979.
Garman L, Pelikan RC, Rasmussen A, Lareau CA, Savoy KA, Deshmukh US, Bagavant H, Levin AM, Daouk S, Drake WP, Montgomery CG. Single Cell Transcriptomics Implicate Novel Monocyte and T Cell Immune Dysregulation in Sarcoidosis. Front Immunol 11:567342, 2020 December, PMID: 33363531, PMCID: PMC7753017
Bagavant H, Deshmukh US. Protocols for Experimental Sjögren’s Syndrome. Curr Protoc Immunol 131:e114, 2020 December, PMID: 33252847
Bagavant H, Michrowska A, Deshmukh US. The NZB/W F1 mouse model for Sjogren’s syndrome: A historical perspective and lessons learned. Autoimmun Rev. 2020 Dec;19(12):102686. doi: 10.1016/j.autrev.2020.102686. Epub 2020 Oct 22. PMID: 33131691 PMCID: PMC7781068 [available on 2021-12-01].
Selected Publications
Papinska J, Bagavant H, Gymrek GB, Deshmukh US. Pulmonary Involvement in a Mouse Model of Sjögren’s Syndrome Induced by STING Activation. Int J Mol Sci. 2020 Jun 25;21(12):4512. doi:10.3390/ijms21124512. PMID: 32630417, PMCID: PMC7349948.
Allushi B, Bagavant H, Papinska J, Deshmukh US. Hyperglycemia and Salivary Gland Dysfunction in the Non-obese Diabetic Mouse: Caveats for Preclinical Studies in Sjögren’s Syndrome. Sci Rep. 2019 Nov 29;9(1):17969. doi: 10.1038/s41598-019-54410-9. PMID: 31784615, PMCID: PMC6884560
Papinska J, Bagavant H, Gmyrek GB, Sroka M, Tummala S, Fitzgerald KA, Deshmukh US. Activation of Stimulator of Interferon Genes (STING) and Sjögren’s Syndrome. J Dent Res. 2018 Jul;97(8):893-900. doi: 10.1177/0022034518760855. Epub 2018 Mar 5. PMID: 29505322, PMCID: PMC6728552.
Szczerba BM, Kaplonek P, Wolska N, Podsiadlowska A, Rybakowska PD, Dey P, Rasmussen A, Grundahl K, Hefner KS, Stone DU, Young S, Lewis DM, Radfar L, Scofield RH, Sivils KL, Bagavant H, Deshmukh US. Interaction between innate immunity and Ro52-induced antibody causes Sjögren’s syndrome-like disorder in mice. Ann Rheum Dis. 2016 Mar;75(3):617-622. doi: 10.1136/annrheumdis-2014-206297. Epub 2015 Feb 5. PMID: 25906316, PMCID: PMC4526450.
Deshmukh US, Bagavant H. When killers become helpers. Sci Transl Med 5: 195fs129, 2013. PMID: 23884464 PMCID: PMC3955842
Szczerba BM, Rybakowska PD, Dey P, Payerhin KM, Peck AB, Bagavant H, Deshmukh US. Type I interferon receptor deficiency prevents murine Sjögren’s syndrome. J Dent Res 92: 444-449, 2013. PMID: 23533183 PMCID: PMC3627507