Presence of circulating autoantibodies reactive with multiple cellular proteins is a characteristic feature of autoimmune disorders such as systemic lupus erythematosus and Sjögren’s syndrome. However, most of the proteins targeted in these disorders are located inside the cells and are shielded from circulating autoantibodies. My laboratory is investigating a basic question, how do autoantibodies recognizing intracellular proteins exert pathogenic effects in autoimmune disorders?
The other major area of research in my laboratory is to understand the mechanisms responsible for the initiation and amplification of autoimmune responses. We are interested in investigating the role of host-microbe interaction in pathogenesis of autoimmune disorders. Our research addresses a critical issue, is bad oral health at a younger age a predisposing factor for autoimmunity